The Expression Frequency of Androgen Receptor, c-erbB2 and CD117 in Acinar Adenocarcinoma of Prostate and Normal Prostate Tissue and It's Clinical Importance

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Mutlu H. S., Aydin O., Baris S., CANBAZ S., Karagöz F.

UROONKOLOJI BULTENI-BULLETIN OF UROONCOLOGY, cilt.14, sa.4, ss.245-250, 2015 (ESCI) identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 14 Sayı: 4
  • Basım Tarihi: 2015
  • Doi Numarası: 10.4274/uob.376
  • Dergi Adı: UROONKOLOJI BULTENI-BULLETIN OF UROONCOLOGY
  • Derginin Tarandığı İndeksler: Emerging Sources Citation Index (ESCI)
  • Sayfa Sayıları: ss.245-250
  • Anahtar Kelimeler: Acinar adenocarcinoma of prostate, CD117, c-erbB2, androgen receptor, immuno-histochemistry
  • Ondokuz Mayıs Üniversitesi Adresli: Evet

Özet

Objective: In the cancer treatment, protein kinase inhibitors targeted at markers such as Her-2/neu (c-erbB2) and c-kit (CD117) are successful approaches. In this study, the expression of c-erbB2 and CD117 in normal prostate tissue as well as with low, moderate and high risk acinar adenocarcinoma of prostate with no androgen-suppression therapy, and, metastatic adenocarcinoma of prostate was investigated and the expression of androgen receptor (AR) was compared with c-erbB2 and CD117.