DD genotype of ACE gene I/D polymorphism is associated with Behcet disease in a Turkish population

YİĞİT S., Tural Ş., RÜSTEMOĞLU A., İNANIR A., Gul U., Kalkan G., ...Daha Fazla

MOLECULAR BIOLOGY REPORTS, cilt.40, sa.1, ss.365-368, 2013 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 40 Sayı: 1
  • Basım Tarihi: 2013
  • Doi Numarası: 10.1007/s11033-012-2069-y
  • Dergi Adı: MOLECULAR BIOLOGY REPORTS
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.365-368
  • Anahtar Kelimeler: Angiotensin-converting enzyme, Behcet's disease, Polymorphism, PREVALENCE, FEVER
  • Ondokuz Mayıs Üniversitesi Adresli: Evet

Özet

Behcet's disease (BD) is a chronic, multi-systemic and inflammatory disorder. The local renin-angiotensin system (RAS) in the vessel wall plays a role in the endothelial control and contributes to inflammatory processes. Angiotensin-converting enzyme (ACE) is the regulatory component of the RAS. This study was conducted in Turkish patients with BD to determine the frequency of I/D polymorphism genotypes of ACE gene. Genomic DNA obtained from 566 persons (266 patients with BD and 300 healthy controls). ACE gene I/D polymorphism genotypes were determined using polymerase chain reaction using I and D allele-specific primers. There was statistically significant difference between the groups with respect to genotype distribution (p < 0.001). This study is the largest study in Turkish population that ACE gene I/D polymorphism investigated in BD. As a result of this study, ACE gene I/D polymorphism DD genotype could be a genetic marker in BD in Turkish study population.