Two new compounds from endemic <i>Centaurea paphlagonica</i> (Bornm.) Wagenitz and their cytotoxic activities

Tufekci A. R., Demirtas İ., Aksit H., Arslan S., Kocabiyik K., Zeybek S., ...Daha Fazla

CHEMICAL BIOLOGY & DRUG DESIGN, cilt.103, sa.1, 2024 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 103 Sayı: 1
  • Basım Tarihi: 2024
  • Doi Numarası: 10.1111/cbdd.14409
  • Dergi Adı: CHEMICAL BIOLOGY & DRUG DESIGN
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Academic Search Premier, BIOSIS, Biotechnology Research Abstracts, CAB Abstracts, Chemical Abstracts Core, EMBASE, MEDLINE, Veterinary Science Database
  • Anahtar Kelimeler: antiproliferative activity, Asteraceae, Centaurea paphlagonica, isolation, MTT
  • Ondokuz Mayıs Üniversitesi Adresli: Evet

Özet

Centaurea paphlagonica (Bornm.) Wagenitz is an endemic plant in Turkey. Pyrocatechol, vanillic acid, 3,4-dihydroxy benzoic acid, 5-O-caffeoylshikimic acid, tamarixetin, chlorogenic acid methyl ester, quercetin, 1,3-dicaffeoylquinic acid, tamarixetin-7-O-beta-D-glucopyranoside, quercimetrin, daucosterin, paphlagonicanin B, tamarixetin-7-O-beta-rutinoside, rutin, chlorogenic acid, isoorientin, orientin, 3-O- feruloylquinic acid, quercetagetin-3-methyl ether 6-O-beta-glucopyranoside, diosmetin 6-C-beta-glucopyranoside, quercetagetin 4 '-methyl ether 7-O-beta-glucopyranoside, paphlagonicanin A, nepetin, cirsiliol, desacylcynaropicrin, and 8 alpha-O-(2 ',3 '- dihydroxyisobutyryl) desacylcynaropicrin were isolated from both flower and aerial parts of C. paphlagonica. These compounds were identified using 1D and 2D NMR methods and ESI-MS. The MTT assay assessed the antiproliferative activities of all isolated (known and new compounds) compounds on Caco-2, LNCaP, A549, HeLa, and HEK-293 cell lines. The 8 alpha-O-(2 ',3 '-dihydroxyisobutyryl) desacylcynaropicrin demonstrated the highest activity against CaCo-2 and HeLa cancer cell lines.