The role of epigenetics in idiopathic male infertility

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Güneş S., Arslan M. A., TAŞKURT HEKİM G. N., Aşcı R.

JOURNAL OF ASSISTED REPRODUCTION AND GENETICS, cilt.33, sa.5, ss.553-569, 2016 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Derleme
  • Cilt numarası: 33 Sayı: 5
  • Basım Tarihi: 2016
  • Doi Numarası: 10.1007/s10815-016-0682-8
  • Dergi Adı: JOURNAL OF ASSISTED REPRODUCTION AND GENETICS
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.553-569
  • Anahtar Kelimeler: Infertility, Epigenetics, DNAmethylation, miRNA, ABERRANT DNA METHYLATION, GENE PROMOTER HYPERMETHYLATION, MICRORNA EXPRESSION PROFILES, INHIBITOR TRICHOSTATIN-A, SEMINAL PLASMA MICRORNAS, MALE REPRODUCTIVE-TRACT, SMALL NONCODING RNAS, NONOBSTRUCTIVE AZOOSPERMIA, ASSISTED REPRODUCTION, IMPRINTED GENES
  • Ondokuz Mayıs Üniversitesi Adresli: Evet

Özet

Infertility is a complex disorder with multiple genetic and environmental causes. Although some specific mutations have been identified, other factors responsible for sperm defects remain largely unknown. Despite considerable efforts to identify the pathophysiology of the disease, we cannot explain the underlying mechanisms of approximately half of infertility cases. This study reviews current data on epigenetic regulation and idiopathic male infertility. Recent data have shown an association between epigenetic modifications and idiopathic infertility. In this regard, epigenetics has emerged as one of the promising research areas in understanding male infertility. Many studies have indicated that epigenetic modifications, including DNA methylation in imprinted and developmental genes, histone tail modifications and short non-coding RNAs in spermatozoa may have a role in idiopathic male infertility.