The effect of IL-4 and MTHFR gene variants in ankylosing spondylitis

YİĞİT S., Inanir A., Tural Ş., Filiz B., Tekcan A.

ZEITSCHRIFT FUR RHEUMATOLOGIE, cilt.74, sa.1, ss.60-66, 2015 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 74 Sayı: 1
  • Basım Tarihi: 2015
  • Doi Numarası: 10.1007/s00393-014-1403-2
  • Dergi Adı: ZEITSCHRIFT FUR RHEUMATOLOGIE
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.60-66
  • Anahtar Kelimeler: Methylenetetrahydrofolate reductase, Interleukin-4, Polymerase chain reaction, Homocysteine, Polymorphism, METHYLENETETRAHYDROFOLATE REDUCTASE, DISEASE-ACTIVITY, TNF-ALPHA, POLYMORPHISM, ASSOCIATION, SUSCEPTIBILITY, HOMOCYSTEINE, POPULATION, CLUSTER, RISK
  • Ondokuz Mayıs Üniversitesi Adresli: Evet

Özet

Ankylosing Spondylitis (AS) is a chronic inflammatory rheumatic disease that characteristically affects the sacroiliac joints and the spine. The exact pathogenesis of AS remains poorly understood, but genetic factors play a key role in disease development. Several genes have been consistently associated with susceptibility to AS. This study was conducted in Turkish AS patients to determine the frequency of the methylenetetrahydrofolate reductase (MTHFR) gene C677T and interleukin-4 (IL-4) gene 70 bp variable number of tandem repeats (VNTR) variants, as well as their association with clinical characteristics.