Promoter methylation analysis of CDH1 and p14ARF genes in patients with urothelial bladder cancer

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Bayramov B., Güneş S., Buyukalpelli R., Aydin O., Henkel R.

ONCOTARGETS AND THERAPY, cilt.11, ss.4189-4196, 2018 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 11
  • Basım Tarihi: 2018
  • Doi Numarası: 10.2147/ott.s158259
  • Dergi Adı: ONCOTARGETS AND THERAPY
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.4189-4196
  • Anahtar Kelimeler: biomarker, CDH1, urine cytology, urothelial bladder cancer, p14ARF, urine, E-CADHERIN GENE, DNA METHYLATION, MULTIPLE GENES, TUMOR-TISSUES, RASSF1A GENES, VOIDED URINE, HYPERMETHYLATION, BIOMARKERS, P16, ARF
  • Ondokuz Mayıs Üniversitesi Adresli: Evet

Özet

Background/aim: Urothelial bladder cancer arises from the accumulation of multiple epigenetic and genetic changes. We aimed to investigate the specificity and sensitivity of gene-specific promoter methylation of CDH1 and p14ARF genes in the early diagnosis of bladder cancer and compare those with other diagnostic tests in our population.