Analysis of Interleukin-1 Receptor Antagonist Variable Number Tandem Repeat Variant in Recurrent Aphthous Stomatitis

Tekcan A., YİĞİT S., NURSAL A. F., TÜMER M. K., YERLİYURT K., Kuruca Şahbazoğlu N.

ENDOCRINE METABOLIC & IMMUNE DISORDERS-DRUG TARGETS, cilt.21, sa.1, ss.139-144, 2021 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 21 Sayı: 1
  • Basım Tarihi: 2021
  • Doi Numarası: 10.2174/1871530320666200413092239
  • Dergi Adı: ENDOCRINE METABOLIC & IMMUNE DISORDERS-DRUG TARGETS
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Biotechnology Research Abstracts, Chemical Abstracts Core, EMBASE, MEDLINE
  • Sayfa Sayıları: ss.139-144
  • Anahtar Kelimeler: Aphthous stomatitis, proinflammatory cytokines, Interleukin-1 Receptor Antagonist, polymerase chain reaction, variable number tandem repeat, variant, IL-1RA GENE POLYMORPHISM, VNTR-POLYMORPHISM, ASSOCIATION, IL1RN-ASTERISK-2, RISK, ULCERATION, ALLELE
  • Ondokuz Mayıs Üniversitesi Adresli: Evet

Özet

Background/Aims: Recurrent aphthous stomatitis (RAS) is one of the common oral inflammatory diseases. As immunological and genetic factors have been held responsible for the pathogenesis of RAS, the objective of this study was to determine whether the interleukin-1 receptor antagonist (IL-1Ra) gene variable number tandem repeat (VNTR) variant is a risk factor for the development of RAS in Turkish patients and to define its contribution to the increased risk.