Pre-eclampsia and eclampsia associated with increased lipid peroxidation and decreased serum vitamin E levels

Yanik F., AMANVERMEZ R., Yanik A., Çelik C., Kökçü A.

International Journal of Gynecology and Obstetrics, cilt.64, sa.1, ss.27-33, 1999 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 64 Sayı: 1
  • Basım Tarihi: 1999
  • Doi Numarası: 10.1016/s0020-7292(98)00161-1
  • Dergi Adı: International Journal of Gynecology and Obstetrics
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.27-33
  • Anahtar Kelimeler: Eclampsia, Lipid peroxidation, MDA, Pre-eclampsia, Vitamin E
  • Ondokuz Mayıs Üniversitesi Adresli: Evet

Özet

Objective: To evaluate lipid peroxidation and the serum levels of the antioxidant vitamin E in pre-eclampsia according to the disease severity. Method: Serum malondialdehyde (MDA) and vitamin E levels were measured in 18 pre-eclamptic, 15 eclamptic and 25 normotensive pregnant women in Ondokuz Mayis University Hospital. The correlation of these levels with the factors indicating disease severity was tested. Mann-Whitney U-test and correlation coefficients were used for the statistical analysis. Result: Both the pre- eclamptic and the eclamptic patients had higher MDA and lower vitamin E levels compared with control (P < 0.05); but these values were not significantly different from each other (P > 0.05). MDA levels were significantly correlated with the systolic and diastolic blood pressure (BP) and with serum uric acid levels. There was significant but negative correlation with the vitamin E levels. Conclusion: There is an imbalance between lipid peroxidation and serum vitamin E levels in pre-eclampsia and eclampsia. Increased lipid peroxidation is well correlated with the increase in systolic and diastolic BP measurements and serum uric acid levels.