Oxidative stress in bipolar and schizophrenia patients

Tunçel Ö. K., SARISOY G., Bilgici B., Pazvantoglu O., Cetin E., Unverdi E., ...Daha Fazla

PSYCHIATRY RESEARCH, cilt.228, sa.3, ss.688-694, 2015 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 228 Sayı: 3
  • Basım Tarihi: 2015
  • Doi Numarası: 10.1016/j.psychres.2015.04.046
  • Dergi Adı: PSYCHIATRY RESEARCH
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Social Sciences Citation Index (SSCI), Scopus
  • Sayfa Sayıları: ss.688-694
  • Anahtar Kelimeler: Protein oxidation, Lipid peroxidation, Oxidized guanine, Glutathione, Superoxide dismutase, Psychiatric disorders, SUPEROXIDE-DISMUTASE ACTIVITY, ATYPICAL ANTIPSYCHOTIC-DRUGS, ACID REACTIVE SUBSTANCES, DNA-DAMAGE, PREFRONTAL CORTEX, NITRIC-OXIDE, MITOCHONDRIAL DYSFUNCTION, GLUTATHIONE DEFICIT, ANTIOXIDANT ENZYMES, LIPID-PEROXIDATION
  • Ondokuz Mayıs Üniversitesi Adresli: Evet

Özet

Oxidative stress has an important place in studies investigating the pathophysiology of psychiatric diseases. In spite of this fact, longitudinal studies are required to clarify the subject. Therefore, in this study, we examined lipid peroxidation, protein oxidation, total oxidized guanine species, superoxide dismutase (SOD) and total glutathione (GSH) levels in blood collected from adult bipolar patients (n=18) during manic and euthymic episodes, schizophrenic patients (n=18) during acute psychotic attack and remission phases and the control group (n=18). There was a significant increase in the level of lipid peroxidation in the bipolar disorder manic episode group (BD-ME) compared to control group. The level of protein oxidation was significantly higher in the schizophrenia acute psychotic attack group (SZ-APA) compared to the control group. The level of total oxidized guanine species was statistically higher in all psychiatric groups compared to the control group. There was no significant difference among the groups with regard to SOD and GSH. Consequently, we believe that lipid peroxidation may be effective in the pathogenesis of bipolar patients; that protein oxidation may be of importance in the pathogenesis of schizophrenia and that total oxidized guanine species may be crucial in the pathogeneses of both psychiatric disorders. (C) 2015 Elsevier Ireland Ltd. All rights reserved.