Pyridoxine and pyridostigmine treatment in vincristine-induced neuropathy

Ozyurek H., Türker H., Akbalik M., Bayrak A. O., Ince H., Duru F.

PEDIATRIC HEMATOLOGY AND ONCOLOGY, cilt.24, sa.5-8, ss.447-452, 2007 (SCI-Expanded) identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 24 Sayı: 5-8
  • Basım Tarihi: 2007
  • Doi Numarası: 10.1080/08880010701451327
  • Dergi Adı: PEDIATRIC HEMATOLOGY AND ONCOLOGY
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.447-452
  • Anahtar Kelimeler: neurotoxicity, pyridostigmine, pyridoxine, vincristine, ACUTE LYMPHOBLASTIC-LEUKEMIA, DIABETES-MELLITUS, THERAPY, PALSY
  • Ondokuz Mayıs Üniversitesi Adresli: Evet

Özet

Vincristine is a commonly used antineoplastic drug and frequently causes neurotoxicity. Here the authors report a 4-year-old boy with acute lymphoblastic leukemia in whom vincristine-induced peripheral and cranial neuropathy developed during remission induction therapy. The patient seemed to benefit from pyridoxine and pyridostigmine therapy greatly and this therapy is recommended in patients with severe vincristine-induced neuropathy.