The relationship between the presence of ADHD and certain candidate gene polymorphisms in a Turkish sample

Pazvantoglu O., Güneş S., Karabekiroglu K., Yegin Z., Erenkus Z., Akbas S., ...Daha Fazla

GENE, cilt.528, sa.2, ss.320-327, 2013 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 528 Sayı: 2
  • Basım Tarihi: 2013
  • Doi Numarası: 10.1016/j.gene.2013.07.004
  • Dergi Adı: GENE
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.320-327
  • Anahtar Kelimeler: Genetics of ADHD, SNAP-25 gene, NET1 gene, 5-HT2A gene, ATTENTION-DEFICIT/HYPERACTIVITY-DISORDER, DEFICIT HYPERACTIVITY DISORDER, SEROTONIN TRANSPORTER GENE, 2A RECEPTOR GENE, ADULT ADHD, NOREPINEPHRINE TRANSPORTER, NO EVIDENCE, MOLECULAR-GENETICS, ASSOCIATION, POPULATION
  • Ondokuz Mayıs Üniversitesi Adresli: Evet

Özet

Due to the high heritability of attention-deficit hyperactivity disorder (ADHD), parents of children with ADHD appear to represent a good sample group for investigating the genetics of the disorder. The aim of this study was to investigate the association between ADHD and six polymorphisms in five candidate genes [5-HT2A (rs6311), NET1 (rs2242447), COMT (rs4818), NTF3 (rs6332), SNAP-25 (rs3746544) and (rs1051312)]. We included 228 parents of children diagnosed with ADHD and 109 healthy parents as the control group. The polymorphisms were genotyped using polymerase chain reaction (PCR) and restriction fragment length polymorphism (RFLP) assays and analyzed using the chi-square test and the multinomial logit model. SNAP-25 (rs3746544) polymorphism was associated with loading for ADHD, while 5-HT2A (rs6311) and NET1 (rs2242447) polymorphisms were associated with ADHD. On the other hand, there was no significant association between the SNAP-25 (rs1051312), NTF3 (rs6332), or COMT (rs4818) gene polymorphisms and ADHD.