Evaluation of the neurotoxic effects of intrathecal administration of (S)-(+)-Ketoprofen on rat spinal cords: randomized controlled experimental study

Kaya C., Atalay Y. O., Can Meydan B., Üstün Y. B., Köksal E., Çalışkan S.

REVISTA BRASILEIRA DE ANESTESIOLOGIA, cilt.69, sa.4, ss.403-412, 2019 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 69 Sayı: 4
  • Basım Tarihi: 2019
  • Doi Numarası: 10.1016/j.bjan.2019.03.006
  • Dergi Adı: REVISTA BRASILEIRA DE ANESTESIOLOGIA
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.403-412
  • Anahtar Kelimeler: Cyclooxygenase inhibitor, Intrathecal injection, (S)-(+)-Ketoprofen, Neurotoxicity, Inflammation, POSTOPERATIVE PAIN, DICLOFENAC SODIUM, KETOROLAC, DRUGS, CYCLOOXYGENASE-1, LIDOCAINE, TOXICITY, FENTANYL, SAFETY, ADULT
  • Ondokuz Mayıs Üniversitesi Adresli: Evet

Özet

Background and objectives: Intrathecal administration of non-steroidal anti-inflammatory drugs is more efficacious for post-operative pain management. Cyclooxygenase inhibiting nonsteroidal anti-inflammatory drugs like (S)-(+)-Ketoprofen, may be effective at lower intrathecal doses than parenteral ones. Preclinical safety regarding possible neurotoxicity associated with the intrathecal (S)-(+)-Ketoprofen was not evaluated. Here we analysed the neurotoxicity of intrathecally administered (S)-(+)-Ketoprofen in rats.