Biological Evaluation of Some Uracil Derivatives as Potent Glutathione Reductase Inhibitors

GÜNEY M., EKİNCİ D., ÇAVDAR H., ŞENTÜRK M., Zilbeyaz K.

International Conference on Advances in Natural and Applied Sciences (ICANAS), Antalya, Türkiye, 21 - 23 Nisan 2016, cilt.1726 identifier identifier

  • Yayın Türü: Bildiri / Tam Metin Bildiri
  • Cilt numarası: 1726
  • Doi Numarası: 10.1063/1.4945930
  • Basıldığı Şehir: Antalya
  • Basıldığı Ülke: Türkiye
  • Ondokuz Mayıs Üniversitesi Adresli: Evet

Özet

Discovery of glutathione reductase (GR) inhibitors has become very popular recently due to antimalarial and anticancer activities. In this study, GR inhibitory capacities of some uracil derivatives (UDCs) (1-4) were reported. Some commercially available molecules (5-6) were also tested for comparison reasons. The novel UDCs were obtained in high yields using simple chemical procedures and exhibited much potent inhibitory activities against GR at low nanomolar concentrations with IC50 values ranging from 2.68 to 166.6 nM as compared with well-known agents.