Regression of Experimentally Induced Endometriosis with a New Selective Cyclooxygenase-2 Enzyme Inhibitor

Kilico I., Kokcu A., Kefeli M., Kandemir B.

GYNECOLOGIC AND OBSTETRIC INVESTIGATION, cilt.77, sa.1, ss.35-39, 2014 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 77 Sayı: 1
  • Basım Tarihi: 2014
  • Doi Numarası: 10.1159/000356686
  • Dergi Adı: GYNECOLOGIC AND OBSTETRIC INVESTIGATION
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.35-39
  • Anahtar Kelimeler: Cyclooxygenase-2, Endometriosis, Enzyme inhibitor, Dexketoprofen trometamol, PROSTAGLANDIN E-2 PRODUCTION, EUTOPIC ENDOMETRIUM, COX-2 INHIBITORS, EXPRESSION, CELLS, APOPTOSIS, WOMEN, DEXKETOPROFEN, MIGRATION, CELECOXIB
  • Ondokuz Mayıs Üniversitesi Adresli: Evet

Özet

Background: Cyclooxygenase-2 (COX-2) levels increase in women with endometriosis. COX-2, via increasing prostaglandin E-2, contributes to an increase in vascular endothelial growth factor. In this way, COX-2 may contribute to the progression and continuity of endometriosis. We investigated the effect of dexketoprofen trometamol, a new selective COX-2 enzyme inhibitor, on experimentally induced endometriotic cysts. Methods: Experimental endometriotic cysts were created in 60 adult female Wistar albino rats. The rats were randomized to 2 equal groups, a control (group Con) and a dexketoprofen (group Dex) group. Six weeks later, cyst volumes were measured as in vivo (volume 1). Following volume 1 measurement, for 4 weeks group Con received 0.1 ml distilled water; group Dex received 0.375 mg dexketoprofen trometamol/0.1 ml distilled water, intramuscularly, twice a day. At the end of administration, the cyst volumes were re-measured (volume 2), and the cysts totally excised and weighed. Glandular (GT) and stromal tissues (ST) and natural killer (NK) cell contents in the cyst wall were scored. Results: NK cell content and volume 1 were not different between the 2 groups. Volume 2, cyst weight, and GT and ST contents in group Dex were significantly lower than those in group Con. Conclusion: Dexketoprofen trometamol significantly reduced the development of experimentally induced endometriotic cysts both macroscopically and microscopically. (C) 2013 S. Karger AG, Basel