Evidence that sodium nitroprusside possesses anticonvulsant effects mediated through nitric oxide

Marangoz C., Ayyıldız M., Ağar E.

NeuroReport, cilt.5, sa.18, ss.2454-2456, 1994 (Scopus) identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 5 Sayı: 18
  • Basım Tarihi: 1994
  • Doi Numarası: 10.1097/00001756-199412000-00012
  • Dergi Adı: NeuroReport
  • Derginin Tarandığı İndeksler: Scopus
  • Sayfa Sayıları: ss.2454-2456
  • Anahtar Kelimeler: Epileptiform activity, Nitric oxide, Sodium nitroprusside
  • Ondokuz Mayıs Üniversitesi Adresli: Evet

Özet

The effect of sodium nitroprusside (SNP) on epileptiform activity elicited by administration of penicillin (500 units) into the somatomotor cortex was studied in anaesthetized rats. No epileptiform activity was observed after intracortical microinjection of SNP (5 and 20 nM). Microinjection of penicillin into the somatomotor cortex induced epileptiform activity in electrocorticograms (ECoG). Epileptiform discharges elicited by penicillin were significantly decreased by SNP. The effect of SNP appeared within 1 min of application and lasted for 2-5 min. The inhibitory effectof SNP on epileptiform activity could be prevented by pretreatment with methylene blue (20 nM), a soluble guanylate cyclase inhibitor. Prior injection of haemoglobin (5 /d), a nitric oxide (NO) scavenger, prevented the anticonvulsant effect of SNP. These results suggest that NO may be an endogenous anticonvulsant substance. © Rapid Communications of Oxford Ltd.