Deep Brain Stimulation of the Rat Subthalamic Nucleus Induced Inhibition of Median Raphe Serotonergic and Dopaminergic Neurotransmission

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Kocabıçak E., Jahanshahi A., Schonfeld L., Hescham S., Temel Y., Tan S.

TURKISH NEUROSURGERY, cilt.25, sa.5, ss.721-727, 2015 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 25 Sayı: 5
  • Basım Tarihi: 2015
  • Doi Numarası: 10.5137/1019-5149.jtn.11230-14.0
  • Dergi Adı: TURKISH NEUROSURGERY
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, TR DİZİN (ULAKBİM)
  • Sayfa Sayıları: ss.721-727
  • Anahtar Kelimeler: Subthalamic nucleus, Median raphe nucleus, Serotonin, Dopamine, Deep brain stimulation, Parkinson's disease, Psychiatric disorders, HIGH-FREQUENCY STIMULATION, ADVANCED PARKINSON-DISEASE, STRIATAL DOPAMINE, CELL-BODIES, NOREPINEPHRINE TRANSPORTERS, HORSERADISH-PEROXIDASE, PREFRONTAL CORTEX, DORSAL, RELEASE, NEURONS
  • Ondokuz Mayıs Üniversitesi Adresli: Evet

Özet

AIM: Deep brain stimulation (DBS) of the subthalamic nucleus (STN) relieves motor dysfunction in advanced Parkinson's disease (PD). However, STN DBS treated patients can experience unpleasant and debilitating psychiatric side effects such as depression and impulsivity. The neural basis of these psychiatric effects has been linked to a dysfunction of 5-hydroxytryptamine (5-HT, serotonin) neurotransmission. STN DBS inhibited activity of 5-HT cell bodies in the dorsal raphe nucleus (DRN). Another important 5-HT source is located in the median raphe nucleus (MRN), which also contains a population of dopamine neurons. The effects of STN DBS on the MRN are unknown. Here, we test the hypothesis that STN DBS reduces 5-HT and dopaminergic function in the MRN, which may contribute to the psychiatric side effects of STN stimulation.