Akademik Veri Yönetim Sistemi
Journal of Experimental and Clinical Medicine (Turkey), cilt.37, sa.2, ss.29-35, 2020 (Scopus)
The aim of this study was to define lung perfusion scintigraphy findings in Behcet's disease (BD) patients with different variations of pulmonary involvement. Medical records and imaging findings of 23 patients with pulmonary involvement of BD were retrospectively reviewed. Before scintigraphic evaluation, patients were classified according to the affected pulmonary vascular level on CT angiography (CTA) as follows: Macroscopic pulmonary vascular involvement (Gr-1) [Pulmonary artery aneurysm without thrombosis (Gr-1a), pulmonary artery aneurysm with thrombosis (Gr-1b), pulmonary artery thrombosis without aneurysm (Gr-1c)]; microscopic pulmonary vascular involvement (Gr-2; no macroscopic CTA findings but with clinical diagnosis and/or scintigraphic abnormality). There were 18 patients in Gr-1 and five patients in Gr-2. Segmental/subsegmental perfusion defects were the most common perfusion pattern and no distinctive pattern was observed among all groups. In 12 patients with macroscopic disease and two patients with microscopic disease, perfusion defects were more extensive than involved vessels on CTA and/or also in the contralateral lung. There were 13 patients with scintigraphic follow-up findings. No change was observed in all Gr-1b and Gr-2 patients; there were heterogeneous changes in 6/7 patients in Gr-1c. No typical perfusion pattern could be demonstrated for a given macroscopic vascular category. In patients with microscopic disease, similarly no characteristic pattern could be defined. As almost all patients with microscopic disease showed perfusion anomalies, scintigraphy may be proposed as a first step examination in case of suspected pulmonary involvement in BD. Scintigraphic follow-up may be of value in pure thrombotic pulmonary involvement.