Multiple Primary Malignant Neoplasms from the Black Sea Region of Turkey

Gürsel Ş. B., Meydan D., Ozbek N., Ozdemir O., Odabas E.

JOURNAL OF INTERNATIONAL MEDICAL RESEARCH, cilt.39, sa.2, ss.667-674, 2011 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 39 Sayı: 2
  • Basım Tarihi: 2011
  • Doi Numarası: 10.1177/147323001103900237
  • Dergi Adı: JOURNAL OF INTERNATIONAL MEDICAL RESEARCH
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.667-674
  • Anahtar Kelimeler: CANCER, MULTIPLE PRIMARY NEOPLASMS, SECONDARY MALIGNANCY, METASTASIS, EPIDEMIOLOGY, NATIONAL-CANCER-CENTER, AUTOPSY, POPULATION, CARCINOMAS, JAPAN, RISK, HEAD
  • Ondokuz Mayıs Üniversitesi Adresli: Evet

Özet

Long-term cancer survival is increasing and, as a consequence, so is the prevalence of secondary malignancies. This study evaluated the patient and tumour characteristics of 117 patients with multiple primary malignant neoplasms (MPMN). The incidence of MPMN in children and adults was 0.28% and 1.23%, respectively. The male : female ratio was 1.7 : 1. The mean +/- SE age at tumour diagnosis was 60.56 +/- 1.18 years. Overall, the top three tumour sites were the larynx, bladder and breast. Among secondary tumours, lung cancer was the most frequent, followed by breast and colon cancer. Among males, the leading primary and secondary tumour sites were the larynx (30.1%) and lung (50.7%), respectively. Among females, the breasts were both the leading primary (32.6%) and secondary (37.2%) cancer site. The mean SE overall survival was 97.2 +/- 15.0 months. During follow-up, the brain was the most commonly observed site of metastasis. The occurrence and characteristics of MPMN reported in the literature are also reviewed. The present study contributes towards increasing understanding and treatment of MPMN in a different population group.