Role of apparent diffusion coefficient measurement in differentiating histological subtypes of brain metastasis of lung cancer

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İncesu L., Abdullayev S., Ozturk M., Aslan K., Gunbey H. P.

REVISTA DA ASSOCIACAO MEDICA BRASILEIRA, cilt.68, sa.9, ss.1318-1323, 2022 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 68 Sayı: 9
  • Basım Tarihi: 2022
  • Doi Numarası: 10.1590/1806-9282.20220630
  • Dergi Adı: REVISTA DA ASSOCIACAO MEDICA BRASILEIRA
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, CAB Abstracts, EMBASE, MEDLINE, Veterinary Science Database, Directory of Open Access Journals
  • Sayfa Sayıları: ss.1318-1323
  • Anahtar Kelimeler: Lung cancer, Brain metastasis, Diffusion weighted MRI, Histological subtype, RISK-FACTORS, TUMORS, EPIDEMIOLOGY
  • Ondokuz Mayıs Üniversitesi Adresli: Evet

Özet

OBJECTIVE: The aim of this study was to investigate the role of apparent diffusion coefficient of diffusion-weighted imaging in differentiating histological subtypes of brain metastasis of lung cancer.METHODS: Diffusion-weighted imaging of 158 patients (mean age: 61.2 +/- 10.68 years) with brain metastasis of lung cancer (36 small cell lung cancer and 122 non-small cell lung cancer) were retrospectively evaluated. The minimum and mean apparent diffusion coefficient values of the metastasis, apparent diffusion coefficient of edema around the metastasis, and apparent diffusion coefficient of contralateral brain parenchyma were measured. Normalized apparent diffusion coefficient was calculated by proportioning the mean apparent diffusion coefficient of the metastasis to the apparent diffusion coefficient of the contralateral brain parenchyma. Minimum and mean apparent diffusion coefficient of the metastasis, apparent diffusion coefficient of edema around metastasis, and normalized apparent diffusion coefficient were compared between small cell lung cancer and non-small cell lung cancer metastases. RESULTS: Minimum apparent diffusion coefficient, mean apparent diffusion coefficient, and normalized apparent diffusion coefficient values of small cell lung cancer metastases (0.43 +/- 0.19x10-3mm2/s, 0.63 +/- 0.20x10-3mm2/s, and 0.81 [0.55-1.44], respectively) were significantly lower than those of non-small cell lung cancer metastases (0.71 +/- 0.26x10-3mm2/s, 0.93 +/- 0.29x10-3mm2/s, and 1.30 [0.60-3.20], respectively; p<0.001). Mean apparent diffusion coefficientof edema of small cell lung cancer metastases (1.21 +/- 0.28x10-3mm2/s) was significantly lower than that of non-small cell lung cancer metastases (1.39 +/- 0.26x10-3mm2/s, p=0.020). The best cutoff values of minimum apparent diffusion coefficient, mean apparent diffusion coefficient, normalized apparent diffusion coefficient, and apparent diffusion coefficient of edema for the differentiation of small cell lung cancer and non-small cell lung cancer were found to be 0.56x10-3mm2/s, 0.82x10-3mm2/s, 1.085, and 1.21x10-3mm2/s, respectively. The area under the receiver operating characteristic curve, sensitivity, and specificity values were, respectively, 0.812, 80.6, and 73.8% for minimum apparent diffusion coefficient; 0.825, 91.7, and 61.5% for mean apparent diffusion coefficient; 0.845, 80.6, and 73.8% for normalized apparent diffusion coefficient; and 0.698, 75.0, and 67.7% for apparent diffusion coefficient of edema.CONCLUSIONS: Minimum apparent diffusion coefficient, mean apparent diffusion coefficient, normalized apparent diffusion coefficient, and apparent diffusion coefficient of edema around metastasis can differentiate histological subtypes of brain metastasis of lung cancer.