In vitro effect of tigecycline against Mycobacterium tuberculosis and a review of the available drugs for tuberculosis

Coban A. Y., Deveci A., Tanrıverdi Çaycı Y., UZUN M., Akgunes A., Durupinar B.

AFRICAN JOURNAL OF MICROBIOLOGY RESEARCH, cilt.5, sa.3, ss.311-315, 2011 (SCI-Expanded) identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 5 Sayı: 3
  • Basım Tarihi: 2011
  • Dergi Adı: AFRICAN JOURNAL OF MICROBIOLOGY RESEARCH
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED)
  • Sayfa Sayıları: ss.311-315
  • Anahtar Kelimeler: Mycobacterium tuberculosis, tigecycline, MICRODILUTION METHOD, BETA-LACTAM, SUSCEPTIBILITY, ANTIMICROBIALS, MEROPENEM, DIAMINE, BROTH, SQ109
  • Ondokuz Mayıs Üniversitesi Adresli: Evet

Özet

The study aimed to investigate the effectiveness of a novel antibiotic drug tigecycline on clinical isolates of Mycobacterium tuberculosis and, reviewing defined anti-tuberculosis effects of available agents. Minimal inhibitory concentration (MIC) of tigecycline for 50 M. tuberculosis including multidrug-resistant (MDR) clinical isolates (20 MDR isolates) was determined by broth microdilution method in the study. Tigecycline MIC values were ranging between 8 and 64 mu g/ml. However, there is not any defined break point for M. tuberculosis resistance. In conclusion, it seems that the in vitro effectiveness of tigecycline to M. tuberculosis is not good but further in vivo studies are needed.