ACTA MEDICA MEDITERRANEA, cilt.36, sa.6, ss.3293-3298, 2020 (SCI-Expanded)
Introduction. Interleukin (IL)-33 is a new member of the IL-1 superfamily. After cellular damage, IL-33 is released into the extracellular space and functions as an alarmin to induce the innate immunity. Recent studies suggest that IL-33 can also induce T helper-1 (Th1), Th2 and Th17 mediated adaptive immune responses. So, as a pro-inflammatory cytokine, IL-33 plays an important role in the pathogenesis of autoimmune and inflammatory diseases. In this recpect, we also assessed the effect of serum IL-33 level in rheumatoid arthritis (RA) and ankylosing spondylitis (AS) which are the most common inflammatory arthritis.