Anxiolytic-like profile of propofol, a general anesthetic, in the plus-maze test in mice

Kurt M., Bilge S. S., Kukula O., Celik S., Kesim Y.

POLISH JOURNAL OF PHARMACOLOGY, cilt.55, sa.6, ss.973-977, 2003 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 55 Sayı: 6
  • Basım Tarihi: 2003
  • Dergi Adı: POLISH JOURNAL OF PHARMACOLOGY
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.973-977
  • Anahtar Kelimeler: propofol, anxiety, elevated plus-maze test, mice, NITRIC-OXIDE, M-CPP, RAT, RECEPTORS, ANXIETY, INHIBITION, ACTIVATION, ADENOSINE, PLASMA
  • Ondokuz Mayıs Üniversitesi Adresli: Hayır

Özet

The present study was performed to investigate the effect of propofol on anxiety using the elevated plus-maze test. Groups of mice received propofol (20, 40, 60 mg/kg) or diazepam (2 mg/ kg), caffeine (3 0 mg/kg), L-arginine (100 mg/kg), m-chlorophenylpiperazine (m-CPP, 2.5 mg/kg) and then were placed in an elevated plus-maze that was composed of two opposite closed arms and two opposite open arms. Propofol (20, 40, 60 mg/kg) and diazepam (2 mg/kg) significantly increased the percentage of time spent in the open arms compared to control. Caffeine (30 mg/kg) and m-CPP (2.5 mg/kg) decreased the percentage of time spent in the open arms and these effects were antagonized when propofol (40 mg/kg) was administered before the test. L-arginine (100 mg/kg) has also produced anxiogenic effect and this effect was not prevented by propofol. All drugs used in this study did not significantly change locomotor activity. These results suggest that propofol has anxiolytic effect in plus-maze test.