Akademik Veri Yönetim Sistemi
Kocatepe Veterinary Journal, cilt.11, sa.2, ss.104-112, 2018 (Hakemli Dergi)
Canine mammary tumors (CMT) included complex interactions in the etiopathogenesis. It is the most common problemof neoplasia in female dogs. The aim of this study was to reveal the roles of chemokine CXC Ligand 12 (CXCL12) and Gprotein coupled receptor 30 (GPCR30) expressions in the inflammatory process and neoplastic development in caninemammary glands. Therefore, after clinical and pathomorphological evaluation, 18 cases of mixed origin malignant forms(mixed-type carcinoma-n=6, complex-type carcinoma-n=3, carcinosarcoma-n=7, carcinoma and malignantmyoepithelioma-n=2)] were examined in the study. Inflammatory cells accompanying neoplastic changes, were determinedto consist of predominantly neutrophils and leukocytes, followed by lymphocytes, plasma cells and macrophages. TheCXCL12 and GPCR30 expressions were scored. immunohistochemically. Most of the expressions for both markers weremoderate in the mammary gland and duct epithelial cells, myoepithelial cells and inflammatory cells. Fibrocytes andfibroblasts gave a mild reaction in general, and no reaction was found in the myxoid, chondroid and osteoid matrix. Therewas considered to be a close relationship between mixed composition CMT and subacute inflammation, and thus it wasconcluded that inflammtory cells may trigger or initiate neoplastic transformation in the cellular environment includingdifferentiated cells of the mammary gland.