Plasma 25-OH Vitamin D3 Level in HIV Infected Patients

Deveci A., Bilgici B.

PROGRESS IN NUTRITION, cilt.23, sa.2, 2021 (SCI-Expanded) identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 23 Sayı: 2
  • Basım Tarihi: 2021
  • Doi Numarası: 10.23751/pn.v23i2.9516
  • Dergi Adı: PROGRESS IN NUTRITION
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, EMBASE
  • Anahtar Kelimeler: Vitamin D, HIV and infection, D DEFICIENCY, ANTIRETROVIRAL THERAPY, D SUPPLEMENTATION, ADULTS, INDIVIDUALS, PREVALENCE, CALCIUM
  • Ondokuz Mayıs Üniversitesi Adresli: Evet

Özet

Vitamin D deficiency affects bone mineral density and immune function and thus may confer adverse outcomes in HIV infected patients. We aimed to determine plasma 25-OH Vit D-3 for evaluation of vitamin D status among HIV infected patients. Medical records were searched retrospectively and data were collected with ethical committee approval. One hundred twenty HIV infected patients who plasma 25-OH Vit D-3 level was determined by liquid chromatography tandem mass spectrophotometer enrolled into the study. Plasma 25-OH Vit D-3 levels of the patients ranged between 4.26 and 68.57 mu g/L (mean: 21.71 +/- 13.08 mu g/L). Normal plasma level (>30 mu g/L) was determined only in 26 (21.6%) patients. Female patients had lower plasma level (11.29 +/- 4.53 vs 24.19 +/- 13.24 mu g/L). There was also negative moderate correlation between age and plasma 25-OH Vit D-3 level (r:-0.42). Correlation between CD4 count and plasma 25-OH Vit D-3 level (r:-0.04) was not determined. In conclusion, majority of HIV infected patients (78.3%) had low level of plasma 25-OH Vit D-3. Therefore, it is important to determine vitamin D status of patients and give replacement therapy for its deficiency during care of HIV infected patients.