Serum Zonulin Levels as an Early Biomarker in Predicting the Severity and Complications of Acute Pancreatitis

AVCIOĞLU U., Eruzun H.

EURASIAN JOURNAL OF MEDICINE, cilt.55, sa.1, ss.78-82, 2023 (ESCI) identifier identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 55 Sayı: 1
  • Basım Tarihi: 2023
  • Doi Numarası: 10.5152/eurasianjmed.2022.0272
  • Dergi Adı: EURASIAN JOURNAL OF MEDICINE
  • Derginin Tarandığı İndeksler: Emerging Sources Citation Index (ESCI), Scopus, Academic Search Premier, CINAHL, Directory of Open Access Journals, TR DİZİN (ULAKBİM)
  • Sayfa Sayıları: ss.78-82
  • Anahtar Kelimeler: Acute pancreatitis, complications, zonulin, bacterial translocation, INTESTINAL PERMEABILITY, ORGAN FAILURE, UP-REGULATION, MANAGEMENT, MODULATOR, MORTALITY, PROTEIN, INJURY, RISK
  • Ondokuz Mayıs Üniversitesi Adresli: Evet

Özet

Objective: Acute pancreatitis can cause local or systemic complications and has high morbidity and mortality rates. In the early stages of pancreatitis, a decrease in the barrier function of the intestines and an increase in bacterial translocation are observed. Zonulin is a marker used to evaluate the integrity of the intestinal mucosal barrier. We aimed to investigate whether measuring serum zonulin levels would contribute to the early prediction of complications and severity in acute pancreatitis.