Akademik Veri Yönetim Sistemi
Journal of health sciences and medicine (Online), cilt.3, sa.3, ss.301-306, 2020 (Hakemli Dergi)
Objective: Current studies have demonstrated that midkine (MK) inhibits the apoptosis in granulosa cells and is responsible for follicular angiogenesis. The aim of this study was to investigate the relation of MK levels and ART outcome. Material and Method: The study included a total of 99 patients who underwent IVF-ICSI at Ondokuz Mayis University between February 2019 and April 2019. Of 99 patients, no embryo development was formed in 1 patient, no oocytes were obtained by oocyte pick up (OPU) in 14 patients and the oocyte cryopreservation was established in 17 patients. In total, 67 patients underwent fresh embryo transfer after IVF-ICSI. On the day of OPU, the level of midkine in serum and follicular fluids were examined. The primary outcome was determined as pregnancy and secondary outcome was determined as blastocyst‐ stage embryos. Results: The level of midkine in serum and follicular fluid was found to be higher in pregnant women compared with non-pregnant women (p=0.042 and p=0.01 respectively). Midkine levels in follicular fluid and serum lead to an increase in blastocyst development. Conclusion: Midkine levels in follicular fluid and serum may lead to an increase in blastocyst development. The level of midkine is higher in pregnant subjects than in non-pregnant subjects.