Is platelet-rich plasma improves the anastomotic healing in hyperthermic intraperitoneal chemotherapy with oxaliplatin: an experimental rat study

Buk O. F., Ocak S., Genç B., Avcı B., Uzuner H. O.

ANNALS OF SURGICAL TREATMENT AND RESEARCH, cilt.98, sa.2, ss.89-95, 2020 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 98 Sayı: 2
  • Basım Tarihi: 2020
  • Doi Numarası: 10.4174/astr.2020.98.2.89
  • Dergi Adı: ANNALS OF SURGICAL TREATMENT AND RESEARCH
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.89-95
  • Anahtar Kelimeler: Anastomotic leak, Colonic neoplasms, Hyperthermia, Oxaliplatin, Platelet-rich plasma, CYTOREDUCTIVE SURGERY, PERITONEAL CARCINOMATOSIS, COLONIC ANASTOMOSIS, CANCER, SURVIVAL, STOMA
  • Ondokuz Mayıs Üniversitesi Adresli: Evet

Özet

Purpose: Hyperthermic intraperitoneal chemotherapy (HIPEC) is a novel treatment option for peritoneal surface malignancies. Due to cytotoxic effects of chemotherapeutic agents, anastomosis healing can be impaired and lead to leakage rates higher than conventional intestinal surgery. In this experimental study, we aimed to investigate the effects of platelet-rich plasma (PRP) on colonic anastomosis in rats that received HIPEC with oxaliplatin.