Determination of the inhibitory effects of N-methylpyrrole derivatives on glutathione reductase enzyme

Kocaoglu E., Talaz O., ÇAVDAR H., ŞENTÜRK M., Supuran C. T., EKİNCİ D.

JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY, cilt.34, sa.1, ss.51-54, 2019 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 34 Sayı: 1
  • Basım Tarihi: 2019
  • Doi Numarası: 10.1080/14756366.2018.1520228
  • Dergi Adı: JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.51-54
  • Anahtar Kelimeler: N-methylpyrrole, coupling, glutathione reductase, antimalaria, antioxidant, IN-VITRO, REDOX, ANTIOXIDANT, ARYLATION, EXTRACT, DRUGS
  • Ondokuz Mayıs Üniversitesi Adresli: Evet

Özet

Glutathione reductase (GR) is a crucial antioxidant enzyme which is responsible for the maintenance of antioxidant GSH molecule. Antimalarial effects of some chemical molecules are attributed to their inhibition of GR, thus inhibitors of this enzyme are expected to be promising candidates for the treatment of malaria. In this work, GR inhibitory properties of N-Methylpyrrole derivatives are reported. It was found that all compounds have better inhibitory activity than the strong GR inhibitor N,N-bis(2-chloroethyl)-N-nitrosourea, especially three molecules, 8 m, 8 n, and 8 q, were determined to be the most powerful among them. Findings of our study indicates that these Schiff base derivatives are strong GR inhibitors which can be used as leads for designation of novel antimalarial candidates.