Relationship between major depressive disorder and ACE gene I/D polymorphism in a Turkish population

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Inanir S., YİĞİT S., Çelikel F. Ç., Ates O., Taycan S. E., Nursal A. F., ...Daha Fazla

Revista de Psiquiatria Clinica, cilt.43, sa.2, ss.27-30, 2016 (SCI-Expanded) identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 43 Sayı: 2
  • Basım Tarihi: 2016
  • Doi Numarası: 10.1590/0101-60830000000077
  • Dergi Adı: Revista de Psiquiatria Clinica
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.27-30
  • Anahtar Kelimeler: Angiotensin-converting enzyme, Major depressive disorder, Polymorphism
  • Ondokuz Mayıs Üniversitesi Adresli: Hayır

Özet

Background: Major depressive disorder (MDD) is a complex disease and a significant health problem that is prevalent across the world. Angiotensin-converting enzyme (ACE) has an important role in renin-angiotensin system (RAS) and converts inactive angiotensin I to a potent vasopressor and aldosterone-stimulating peptide angiotensin II. Levels of ACE in plasma vary according to the insertion/deletion (I/D) polymorphism of ACE gene. Objective: The aim of the current study was to examine the influence ACE gene I/D variations on the risk of MDD. Methods: In the present case-control study, we analyzed ACE I/D polymorphism in 346 MDD patients and 210 healthy subjects using polymerase chain reaction technique. Results: Comparing the two groups, no significant difference was observed with regard to either genotype distributions or allele frequencies of the I/D polymorphism of ACE gene. Discussion: Our findings suggest that the ACE I/D polymorphism is not associated with MDD in Turkish case-control study. Further studies are still needed.