Microtubular Dysfunction and Male Infertility

Güneş S., Sengupta P., Henkel R., Alguraigari A., Sinigaglia M. M., Kayal M., ...Daha Fazla

WORLD JOURNAL OF MENS HEALTH, cilt.38, sa.1, ss.9-23, 2020 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Derleme
  • Cilt numarası: 38 Sayı: 1
  • Basım Tarihi: 2020
  • Doi Numarası: 10.5534/wjmh.180066
  • Dergi Adı: WORLD JOURNAL OF MENS HEALTH
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Academic Search Premier, Directory of Open Access Journals
  • Sayfa Sayıları: ss.9-23
  • Anahtar Kelimeler: Axoneme, Infertility, male, Kartagener syndrome, Microtubule-associated proteins, PRIMARY CILIARY DYSKINESIA, FIBROUS SHEATH, INTRAMANCHETTE TRANSPORT, SPERM FLAGELLA, KATANIN P80, DYNEIN, GENE, MUTATIONS, PROTEIN, EXPRESSION
  • Ondokuz Mayıs Üniversitesi Adresli: Evet

Özet

Microtubules are the prime component of the cytoskeleton along with microfilaments. Being vital for organelle transport and cellular divisions during spermatogenesis and sperm motility process, microtubules ascertain functional capacity of sperm. Also, microtubule based structures such as axoneme and manchette are crucial for sperm head and tail formation. This review (a) presents a concise, yet detailed structural overview of the microtubules, (b) analyses the role of microtubule structures in various male reproductive functions, and (c) presents the association of microtubular dysfunctions with male infertility. Considering the immense importance of microtubule structures in the formation and maintenance of physiological functions of sperm cells, this review serves as a scientific trigger in stimulating further male infertility research in this direction.