Proconvulsant Effect of Papaverine on Penicillin-Induced Epileptiform Activity in Rats

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Marangoz A. H., Kocacan S. E., Him A., Kuruoglu E., Çokluk C., MARANGOZ C.

TURKISH NEUROSURGERY, cilt.28, sa.3, ss.479-482, 2018 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 28 Sayı: 3
  • Basım Tarihi: 2018
  • Doi Numarası: 10.5137/1019-5149.jtn.19703-17.2
  • Dergi Adı: TURKISH NEUROSURGERY
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, TR DİZİN (ULAKBİM)
  • Sayfa Sayıları: ss.479-482
  • Anahtar Kelimeler: Epilepsy, Female rat, Papaverine, Penicillin, ANEURYSMAL SUBARACHNOID HEMORRHAGE, CEREBRAL VASOSPASM, INTRAARTERIAL PAPAVERINE, ENDOVASCULAR MANAGEMENT, INDUCED SEIZURES, NITRIC-OXIDE, EPILEPSY, INHIBITION, ADENOSINE
  • Ondokuz Mayıs Üniversitesi Adresli: Evet

Özet

AIM: Papaverine is a vasodilator agent that is an opium alkaloid. It exhibits its effects by inhibiting the phosphodiesterase enzyme. Papaverine administration is widely used to avoid symptomatic vasospasm after subarachnoid hemorrhage. We aimed, in this research, to study the effects of papaverine on the epileptic discharges stimulated by penicillin.