Overexpression of bcl-2 in lymphocytes of psoriatic skin

Yildiz, Levent; Baris, S; Senturk, N; Kandemir, B

doi:10.1046/j.1468-3083.2003.00805.x

Overexpression of bcl-2 in lymphocytes of psoriatic skin

Atıf İçin Kopyala

Yildiz L., Baris S., Senturk N., Kandemir B.

JOURNAL OF THE EUROPEAN ACADEMY OF DERMATOLOGY AND VENEREOLOGY, cilt.17, sa.5, ss.538-540, 2003 (SCI-Expanded)

Yayın Türü: Makale / Tam Makale
Cilt numarası: 17 Sayı: 5
Basım Tarihi: 2003
Doi Numarası: 10.1046/j.1468-3083.2003.00805.x
Dergi Adı: JOURNAL OF THE EUROPEAN ACADEMY OF DERMATOLOGY AND VENEREOLOGY
Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
Sayfa Sayıları: ss.538-540
Anahtar Kelimeler: bcl-2, psoriasis, T-CELLS, APOPTOSIS, EXPRESSION, PROTEIN, PATHOGENESIS
Ondokuz Mayıs Üniversitesi Adresli: Evet

Özet

Bcl-2 overexpression in lymphocytes play an important part in immunological and inflammatory diseases. In the present study, we investigated the bcl-2 expression in dermal lymphocytes of psoriatic skin biopsy samples. From the archives of the Department of Pathology, Ondokuz Mayis University Medical School (Samsun, Turkey), tissue sections belonging to 28 psoriasis cases and 10 chronic non-specific inflammatory skin disease cases were immunohistochemically stained by bcl-2. Positive staining was semiquantitatively graded from 1 + to 4 +. Of the 28 psoriasis cases 20 were found to express bcl-2. Our data suggest that bcl-2-mediated inflammation plays a part in the pathogenesis and recurrent character of psoriasis.