The changes in lipid peroxidation and GSH levels in the cerebellum of rats induced by ethanol consumption are prevented by vitamin E

Ağar E., Demir Ş., AMANVERMEZ R., Boşnak M., Ayyıldız M., Çelik C.

Neuroscience Research Communications, cilt.27, sa.3, ss.191-197, 2000 (SCI-Expanded) identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 27 Sayı: 3
  • Basım Tarihi: 2000
  • Dergi Adı: Neuroscience Research Communications
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.191-197
  • Anahtar Kelimeler: Cerebellum, Glutathione, Lipid peroxidation, Vitamin E
  • Ondokuz Mayıs Üniversitesi Adresli: Evet

Özet

The present study used male Wistar rats to investigate changes in glutathione (GSH) and lipid peroxidation (TBARS) in the cerebellum of 10%, 25%, 35% ethanol-consuming rats with or without vitamin E treatment when compared to the control group, the level of lipid peroxidation was increased 58.3%, 68.7%, 66.7% in rats consuming 10%, 25%, 35% ethanol, respectively. Ethanol decreased GSH levels in the cerebellum. This decrease was dose-dependent with 23.7%, 27.6%, 28% decreases in GSH in the cerebellum of rats consuming 10%, 25% or 35% ethanol, respectively. Vitamin E (100 mg/kg/day, i.p) treatment prevented the increase in the lipid peroxidation and decreases in cerebellum GSH levels of ethanol-consuming rats.