IL-4 and MTHFR gene polymorphism in rheumatoid arthritis and their effects

İNANIR A., YİĞİT S., Tekcan A., Tural Ş., Kismali G.

IMMUNOLOGY LETTERS, cilt.152, sa.2, ss.104-108, 2013 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 152 Sayı: 2
  • Basım Tarihi: 2013
  • Doi Numarası: 10.1016/j.imlet.2013.05.004
  • Dergi Adı: IMMUNOLOGY LETTERS
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.104-108
  • Anahtar Kelimeler: Rheumatiod arthritis, Interleukin-4 gene (IL-4), Methylenetetrahydrofolate reductase gene (MTHFR), Polymorphism, INTERLEUKIN-4 GENE, PLASMA HOMOCYSTEINE, CHINESE PATIENTS, ASSOCIATION, METHOTREXATE, REDUCTASE, DISEASE, INVOLVEMENT, VARIANTS, HEART
  • Ondokuz Mayıs Üniversitesi Adresli: Evet

Özet

Rheumatoid arthritis (RA) is a chronic, systemic inflammatory disease that mainly affects the joints. Polymorphic variations of the cytokine genes and MTHFR gene have received attention as potential markers of susceptibility, severity, and/or protection in RA. The aim of this study was to investigate the MTHFR C677T and IL-4 70 bp VNTR variation in Turkish patients with RA and evaluate if there was an association with clinical features, especially ocular involvement, in RA patients.