Akademik Veri Yönetim Sistemi
Experimental and Clinical Cardiology, cilt.20, sa.6, ss.4189-4209, 2014 (Scopus)
Purpose: In this study, we aimed to investigate the effect of insulin resistance on coronary collateral development in nondiabetic patients with total coronary artery occlusion. Methods: This study was comprised of 40 nondiabetic patients (mean age 61.65 ± 8.99 years) whose coronary angiography, performed with a prediagnosis of coronary artery disease, showed total occlusion in only one of the coronary arteries. Collateral development was classified in reference to the Rentrop classification. Insulin resistance levels were measured by the Homeostasis Model Assessment of Insulin Resistance (HOMA-IR) method. The patients with poor collateral (Group 1; n = 20; Rentrop grades of 0 and 1) and good collateral (Group 2; n = 20; Rentrop grades of 2 and 3) were compared in terms of insulin resistance. Results: When the basic characteristics of both groups were evaluated, no differences were found between the groups in terms of age, gender, smoking, body mass index (BMI), and the presence of hypertension. There were also no significant differences in terms of biochemical parameters including TSH, LDL, HDL, triglycerides, hemoglobin, and HbA1c. However, a significant difference was found between the groups in terms HOMA-IR (3.40 ± 3.45 vs. 1.20 ± 1.35, p = 0.001), fasting plasma glucose levels (93.75 ± 13.5 vs. 84.15 ± 14.76 mg/dl, p = 0.039), and fasting plasma insulin levels (14.2 ± 13.2 vs. 5.3 ± 5.1 μIU/ml, p = 0.002) for Group 1 and Group 2, respectively. Conclusion: The results of this study revealed that insulin resistance level was statistically significantly high in the nondiabetic patients with total coronary occlusion and with poor collateral development as compared to those with good collateral development.