Oxidative Stress Induced by Ureteral Obstruction and Tadalafil

CIRRIK S., Ayyildiz S. N., BENLİ E., Ayyildiz A., NOYAN T., Germiyanoğlu R. C., ...Daha Fazla

JOURNAL OF ACADEMIC RESEARCH IN MEDICINE-JAREM, cilt.7, sa.1, ss.11-15, 2017 (ESCI) identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 7 Sayı: 1
  • Basım Tarihi: 2017
  • Doi Numarası: 10.5152/jarem.2017.1109
  • Dergi Adı: JOURNAL OF ACADEMIC RESEARCH IN MEDICINE-JAREM
  • Derginin Tarandığı İndeksler: Emerging Sources Citation Index (ESCI), TR DİZİN (ULAKBİM)
  • Sayfa Sayıları: ss.11-15
  • Anahtar Kelimeler: PDE5, tadalafil, ureter, obstruction, oxidative stress, PHOSPHODIESTERASE TYPE 5, ISCHEMIA/REPERFUSION INJURY, INHIBITOR, EXPRESSION, RATS
  • Ondokuz Mayıs Üniversitesi Adresli: Evet

Özet

Objective: It has been reported that tadalafil, a specific phosphodiesterase-5 (PDE5) inhibitor, has an antioxidant effect besides its well-known vasoactive properties. This study aimed to determine the possible protective effects of tadalafil in managing renal oxidative stress induced by unilateral ureteral obstruction (UUO).