Chromosomal abnormalities in couples with recurrent pregnancyloss Tekrarlayan düşükleri olan çiftlerde kromozom anomalileri

Ökten G., Güneş S., Kara N., Tural Ş., YİĞİT S., Taşkin E.

Ondokuz Mayis Universitesi Tip Dergisi, cilt.24, sa.3, ss.90-94, 2007 (Scopus) identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 24 Sayı: 3
  • Basım Tarihi: 2007
  • Dergi Adı: Ondokuz Mayis Universitesi Tip Dergisi
  • Derginin Tarandığı İndeksler: Scopus
  • Sayfa Sayıları: ss.90-94
  • Anahtar Kelimeler: Chromosomal disorders, Cytogenetic analysis, Recurrent miscarriage
  • Ondokuz Mayıs Üniversitesi Adresli: Evet

Özet

Recurrent miscarriages affect approximately 5% of couples trying to establish a family. In this study we have investigated the chromosomal constitution of couples of with recurrent pregnancy losses in order to determine chromosomal anomaly frequencies. Samples of venous blood were obtained from 318 couples with recurrent miscarriages. Karyotyping was performed on peripheral blood lymphocytes (PBL) according to standard methods and 20 G-banded metaphases were analyzed in each case. We found abnormal chromosomes in 2.2% of patients. We conclude that patients with recurrent miscarriages should be routinely karyotyped.