Akademik Veri Yönetim Sistemi
Ondokuz Mayis Universitesi Tip Dergisi, cilt.18, sa.2, ss.71-79, 2001 (Scopus)
In this study, we evaluated 230 children (0 to 17 years old) with nephrotic syndrome (NS) who admitted to the Department of Pediatrics of Ondokuz Mayas University between January 1986 to December 1998, retrospectively. The diagnostic criteria of International Study of Kidney Diseases of Children (ISKDC) were used to define the patients in this study. Patients were classified into two groups according to etiology as primary and secondary NS. Clinical and laboratory findings of all cases were examined. It is observed that 77.8% of the cases had primary and 17.4% had secondary NS, 4.8% of them could not be classified, 39.1% of the patients were female and 60.9% of them were male. Female/male ratio was 1/1.6. Steroid responsive cases consisted 77.8% of the cases with minimal change NS [MCNS), 51% of the patients with steroid responsive MCNS developed one or more relapses. Among the relapses, rare and frequent relapses were 29.4% and 10.7%, respectively. 3.9% of the patients with MCNS were steroid dependent. Amyloidosis was diagnosed in 27 patients and it was the most common cause of secondary NS, The most frequent complication was infection. In 230 patients, 57.4% went to remission, 5.6% died and 10.4% progressed to chronic renal failure. These findings were evaluated according to age, sex, etiology, response to treatment, prognosis and compared with national data and the literature.