Ranitidine and somatostatin for prophylaxis of stress ulcer in rats

Rizalar R., Sarac A., Gork S., Barış S., Bernay F., Gurses N.

Turkish Journal of Medical Sciences, cilt.24, sa.4, ss.301-303, 1995 (Scopus) identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 24 Sayı: 4
  • Basım Tarihi: 1995
  • Dergi Adı: Turkish Journal of Medical Sciences
  • Derginin Tarandığı İndeksler: Scopus
  • Sayfa Sayıları: ss.301-303
  • Anahtar Kelimeler: ranitidine, somatostatin, stress ulcer
  • Ondokuz Mayıs Üniversitesi Adresli: Evet

Özet

The effects of somatostatin and ranitidine on prophylaxis of stress ulcer are compared using three experimental groups of rats: Sham group, ranitidine group, and somatostatin group. Gastric mucosal damage index was measured in each group and Mann-Whitney U test was used for statistical analysis. Statistically, there was not any difference between the sham and the ranitidine groups (p > 0.05), but the mucosal damage index in the somatostatin group was significantly lower then in the sham and the ranitidine groups (p < 0.01). Somatostatin seems to be a more effective drug than ranitidine for the prophylaxis of stress ulcers.