Clinical management of metformin overdose: A case report

Çolak Ş., Erdoğan M. Ö., Yavuz B. G., Akdemir H. U., Ceppioğlu S. K., Yurdun T.

Journal of Experimental and Clinical Medicine (Turkey), cilt.34, sa.3, ss.203-205, 2017 (Scopus) identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 34 Sayı: 3
  • Basım Tarihi: 2017
  • Doi Numarası: 10.5835/jecm.omu.34.03.009
  • Dergi Adı: Journal of Experimental and Clinical Medicine (Turkey)
  • Derginin Tarandığı İndeksler: Scopus, TR DİZİN (ULAKBİM)
  • Sayfa Sayıları: ss.203-205
  • Anahtar Kelimeler: Hemofiltration, Hypoglycemia, Lactic acidosis, Metformin, Overdose
  • Ondokuz Mayıs Üniversitesi Adresli: Evet

Özet

Metformin is first-line therapy in diabetes mellitus treatment. Metformin intoxication may cause lactic acidosis. A 29-year-old woman presented to our emergency department with loss of consciousness. Arterial blood gas revealed severely increased anion gap lactic acidosis. Continuous venovenous hemofiltration was performed for 39 h. After extracorporeal treatment, the acidosis resolved and the patient became conscious. There is no specific treatment for metformin intoxication; current treatment is supportive only. Our aim is to highlight the diagnosis, chromatographic measurement of the drug blood level, and management of metformin overdose.