The frequency of retrotransposon human endogenous retrovirus-K113 and a preliminary analysis of some microbial clues in bipolar disorder

YEĞİN Z., AVŞAR C., SARISOY G.

FUTURE MICROBIOLOGY, cilt.15, sa.17, 2020 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 15 Sayı: 17
  • Basım Tarihi: 2020
  • Doi Numarası: 10.2217/fmb-2020-0166
  • Dergi Adı: FUTURE MICROBIOLOGY
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, BIOSIS, CAB Abstracts, Chemical Abstracts Core, EMBASE, MEDLINE, Veterinary Science Database
  • Anahtar Kelimeler: bipolar disorder, HERV-K113, human endogenous retrovirus, microbiota, retrotransposon, STRAND-CONFORMATION POLYMORPHISM, INSERTIONAL POLYMORPHISMS, BACTERIAL COMMUNITIES, GENETIC PROFILES, HERV-K113, DIVERSITY, IDENTIFICATION, RHIZOSPHERES, GENOME
  • Ondokuz Mayıs Üniversitesi Adresli: Evet

Özet

Aim: The aim of our study was to investigate whether the retrotransposon human endogenous retrovirus (HERV)-K113 could be related with bipolar disorder or not. As a second and a preliminary aim, we also conducted bacterial screening in whole blood in a limited number of samples. Patients & methods: Three separate PCR reactions including the preintegration sites and sites within the viral sequences were performed for HERV-K113 detection. Bacterial screening was performed with SSCP/sequencing analysis. Results & conclusion: No difference was observed in terms of the frequency of retrotransposon HERV-K113 in Turkish bipolar disorder patients and healthy controls. SSCP/sequencing and alignment analysis for bacterial screening reflected the possible presence of different bacteria. We strongly recommend the broadened retrotransposon and microbial diversity analyses in bipolar disorder for future studies.