The association between platelet/lymphocyte ratio, neutrophil/lymphocyte ratio, and carotid artery stenosis and stroke following carotid endarterectomy

Deser S. B., Yücel S. M., Demirağ M. K., Güçlü M. M., Kolbakır F., Keçeligil H. T.

VASCULAR, cilt.27, sa.6, ss.604-611, 2019 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 27 Sayı: 6
  • Basım Tarihi: 2019
  • Doi Numarası: 10.1177/1708538119847390
  • Dergi Adı: VASCULAR
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.604-611
  • Anahtar Kelimeler: Platelet-to-lymphocyte ratio, neutrophil-to-lymphocyte ratio, mean platelet volume, carotid endarterectomy, stroke, MEAN PLATELET VOLUME, TO-LYMPHOCYTE RATIO, ISCHEMIC-STROKE, SEVERITY, ATHEROSCLEROSIS, INFLAMMATION, PREDICTOR, MORTALITY, MARKER
  • Ondokuz Mayıs Üniversitesi Adresli: Evet

Özet

Objectives Platelet/lymphocyte ratio is considered to be a recent biomarker which is not only related with inflammation but also associated with the atherosclerotic process. In this study, we aimed to investigate the relationship between carotid artery stenosis, platelet/lymphocyte ratio, neutrophil/lymphocyte ratio, and mean platelet volume in patients undergoing carotid endarterectomy. Methods A total of 160 patients (127 males, 33 females; mean age 69.98 +/- 9.76 years; range 48-92 years), who were undergoing carotid endarterectomy due to severe carotid artery stenosis, were evaluated and compared with 201 patients (140 males, 61 females, mean age 66.30 +/- 9.24 years, range 41-90 years) without severe carotid artery stenosis. The patients were divided into four groups with respect to the carotid artery stenosis as: Group I (<50% stenosis), Group II (50-70% stenosis), Group III (70-90% stenosis), and Group IV (90-99% stenosis). Results Platelet/lymphocyte ratio, neutrophil/lymphocyte ratio and mean platelet volume were found higher in Group IV (patients with severe carotid artery stenosis) (p < 0.01) and were positively correlated with the degree of stenosis (p < 0.01). Platelet/lymphocyte ratio is an independent predictor for post operative stroke (p = 0.047) at multivariate analysis. A threshold level of 145.304 of platelet/lymphocyte ratio combined with a sensitivity 83.3% and specificity 73.8% (95% CI, 0.802-0.921, area under the curve = 0.862 +/- 0.03; p = 0.002) for the identification of post operative stroke. Conclusions This retrospective study suggests that platelet/lymphocyte ratio in the blood which was taken preoperatively could be considered as an additional, easy, and inexpensive method to predict a possible higher incidence of postoperative stroke after carotid endarterectomy.