Evaluation of Antinociceptive and Neurotoxic Effects of Intrathecal Dexmedetomidine in Rats

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Isguzar O., Barış S., Bozkurt A., Can Meydan B., Bilge S. S., Ture H.

BALKAN MEDICAL JOURNAL, cilt.29, sa.4, ss.354-357, 2012 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 29 Sayı: 4
  • Basım Tarihi: 2012
  • Doi Numarası: 10.5152/balkanmedj.2012.034
  • Dergi Adı: BALKAN MEDICAL JOURNAL
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, TR DİZİN (ULAKBİM)
  • Sayfa Sayıları: ss.354-357
  • Anahtar Kelimeler: Dexmedetomidine, intrathecal, neurotoxicity, histopathology, rat, SPINAL-CORD, CLONIDINE, ANTAGONIST, AGONIST, BUPIVACAINE, ANALGESIA, EFFICACY, PAIN
  • Ondokuz Mayıs Üniversitesi Adresli: Evet

Özet

Objective: Dexmedetomidine has been reported to produce analgesia after intrathecal administration. In the present study the alpha 2-adrenoceptor agonist dexmedetomidine was evaluated for its potential spinal neurotoxic effects.