Evaluation of gingival alterations in rats medicated with cyclosporine A, tacrolimus and sirolimus: a stereological study

Pamuk F., Cetinkaya B. O., Ayas B., Keles G. C., Gacar A.

JOURNAL OF PERIODONTAL RESEARCH, cilt.50, sa.5, ss.629-636, 2015 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 50 Sayı: 5
  • Basım Tarihi: 2015
  • Doi Numarası: 10.1111/jre.12243
  • Dergi Adı: JOURNAL OF PERIODONTAL RESEARCH
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.629-636
  • Anahtar Kelimeler: animal model, cyclosporine A, gingival overgrowth, sirolimus, tacrolimus, RENAL-TRANSPLANT RECIPIENTS, MTOR INHIBITION, RISK-FACTORS, OVERGROWTH, RAPAMYCIN, PREVALENCE, THERAPY, IMMUNOSUPPRESSANTS, ENLARGEMENT, CONVERSION
  • Ondokuz Mayıs Üniversitesi Adresli: Evet

Özet

Background and ObjectiveIt has previously been shown that both cyclosporine A and tacrolimus cause gingival overgrowth in the rat. We proposed that sirolimus may play an important role in decreasing the severity of gingival overgrowth. Therefore, the aim of this study was to evaluate the gingival changes induced by immunosuppressants, in the presence and absence of sirolimus, using histopathology and stereological methods.