The role of A268V exon-7 polymorphism of PPARA in development of axial spondyloarthritis

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Akbulut E., YOLBAŞ S., Özgen M.

TURKISH JOURNAL OF BIOCHEMISTRY-TURK BIYOKIMYA DERGISI, cilt.47, sa.1, ss.103-111, 2022 (SCI-Expanded) identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 47 Sayı: 1
  • Basım Tarihi: 2022
  • Doi Numarası: 10.1515/tjb-2021-0086
  • Dergi Adı: TURKISH JOURNAL OF BIOCHEMISTRY-TURK BIYOKIMYA DERGISI
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Academic Search Premier, EMBASE, Food Science & Technology Abstracts, Directory of Open Access Journals, TR DİZİN (ULAKBİM)
  • Sayfa Sayıları: ss.103-111
  • Anahtar Kelimeler: axial spondyloarthritis, disease risk, inflammation, peroxisome proliferator activated receptor alpha, polymorphism, PROLIFERATOR-ACTIVATED RECEPTOR, PROTEIN, MUTATIONS, RECOGNITION, PREVALENCE, MECHANISMS, SERVER, GENE
  • Ondokuz Mayıs Üniversitesi Adresli: Evet

Özet

Objectives: Axial spondyloarthritis (axSpA) is a chronic inflammatory disease that mainly affects the axial skeleton. Peroxisome proliferator activated receptor alpha (PPARA) is an intracellular transcription factor, which play a role in inflammation and osteoblasting activity. This study is designed to investigate the relationship of NG_012204.2:p.A1a268Val polymorphism of PPARA with axSpA risk and its role in disease development.