Clinical Outcomes of Patients with High-Grade Ovarian Carcinoma Arising in Endometriosis Compared to Ovarian High-Grade Serous Carcinoma

Yalçın İ., Sahin H., Sari M. E., HABERAL REYHAN A. N., Sahin E. A., Celik H., ...Daha Fazla

INDIAN JOURNAL OF GYNECOLOGIC ONCOLOGY, cilt.19, sa.4, 2021 (ESCI) identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 19 Sayı: 4
  • Basım Tarihi: 2021
  • Doi Numarası: 10.1007/s40944-021-00559-z
  • Dergi Adı: INDIAN JOURNAL OF GYNECOLOGIC ONCOLOGY
  • Derginin Tarandığı İndeksler: Emerging Sources Citation Index (ESCI), Scopus
  • Anahtar Kelimeler: Endometriosis, High-grade serous ovarian carcinoma, Ovarian endometrioid carcinoma, Ovarian clear cell carcinoma, Survival analysis, CLEAR-CELL CARCINOMA, PROGNOSTIC-FACTOR, TUMOR TYPE, CANCER, SURVIVAL, WOMEN
  • Ondokuz Mayıs Üniversitesi Adresli: Evet

Özet

Purpose To compare the prognoses of women with high-grade ovarian carcinoma arising in endometriosis (OCAE) to those of women with ovarian high-grade serous carcinoma (HGSC) Material and Methods This multicenter, retrospective, case-control study included patients with OCAE at two gynecologic oncology centers in Turkey between January 2006 and December 2016. Of a total of 202 women with a diagnosis of OCAE, 70 women with high-grade OCAE were included. Each case high-grade OCAE was attributed to two women with ovarian HGSC. Survival analysis was performed using the Kaplan-Meier method. Results Eleven patients with high-grade OCAE had recurrent disease (15.7%) when compared to 47 patients (33.6%) with HGSC (p = 0.008). The 5-year disease-free survival (DFS) rate of the patients having high-grade OCAE was significantly higher than the women with HGSC (78.3% vs. 56.2%; p = 0.007, respectively). According to the 5-year overall survival (OS) rates, there was no significant difference between high-grade OCAE and HGSC (79.5% vs. 70.1%; p = 0.210, respectively). Conclusion Although this retrospective study demonstrated a significant decrease in recurrence rate and an increase in the 5-year DFS rate in patients with high-grade OCAE, OS rates of the patients with HGSC and high-grade OCAE seem to be similar.