Protection of nigral cell death by bilateral subthalamic nucleus stimulation

Temel Y., Visser-Vandewalle V., Kaplan S., Kozan R., Daemen M. A. R. C., Blokland A., ...Daha Fazla

BRAIN RESEARCH, cilt.1120, ss.100-105, 2006 (SCI-Expanded) identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 1120
  • Basım Tarihi: 2006
  • Doi Numarası: 10.1016/j.brainres.2006.08.082
  • Dergi Adı: BRAIN RESEARCH
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.100-105
  • Anahtar Kelimeler: subthalamic nucleus, deep brain stimulation, dopamine, Parkinson disease, protection, DEEP BRAIN-STIMULATION, HIGH-FREQUENCY STIMULATION, PARKINSONS-DISEASE, DOPAMINERGIC-NEURONS, SUBSTANTIA-NIGRA, NITRIC-OXIDE, FOLLOW-UP, RAT, NEUROGENESIS, SURVIVAL
  • Ondokuz Mayıs Üniversitesi Adresli: Evet

Özet

In Parkinson disease (PD), the subthalamic nucleus (STN) becomes hyperactive (disinhibited), which is reported to cause excitotoxic damage to midbrain dopaminergic neurons. Here, we examined whether silencing of the hyperactive STN by chronic bilateral deep brain stimulation (DBS) increased the survival of midbrain dopaminergic neurons in a rat model of PD. High-precision design-based stereologic examination of the total number of neurons and tyrosine tydroxylase (TH) immunoreactive neurons in the substantia. nigra. pars compacta revealed that STN DBS resulted in a significant survival of these neurons. These data provide the first evidence in vivo that bilateral STN DBS is useful for protecting midbrain dopaminergic neurons from cell death in PD. (c) 2006 Elsevier B.V. All rights reserved.