Increased expression of vascular endothelial growth factor in cyclosporin A-induced gingival overgrowth in rats

Cetinkaya B. O., Acikgoz G., Ayas B., Aliyev E., Sakallioglu E. E.

JOURNAL OF PERIODONTOLOGY, cilt.77, sa.1, ss.54-60, 2006 (SCI-Expanded) identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 77 Sayı: 1
  • Basım Tarihi: 2006
  • Doi Numarası: 10.1902/jop.2006.77.1.54
  • Dergi Adı: JOURNAL OF PERIODONTOLOGY
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.54-60
  • Anahtar Kelimeler: angiogenesis, cyclosporin A, gingival overgrowth, vascular endothelial growth factor, ANGIOGENESIS, HYPERPLASIA, VEGF, INHIBITION, NIFEDIPINE, PHENYTOIN, MECHANISM, THERAPY, DISEASE, BIOLOGY
  • Ondokuz Mayıs Üniversitesi Adresli: Evet

Özet

Background: Gingival overgrowth is a side effect associated with cyclosporin A (CsA) therapy. The lesion is characterized by increased epithelial thickness, enlargement of connective tissue, and increased vascularization. The aim of this experimental study was to examine the role of vascular endothelial growth factor (VEGF) in the pathogenesis of CsA-induced gingival overgrowth.