Bone mineral density in patients receiving isotretinoin and acitretin İzotretinoin ve asitretin kullanan hastalarda kemik mineral yoǧunluklari

Cantürk F., Saraç N., Aydın F., Tosun F. C., Alaylı G., Akyol Y., ...Daha Fazla

Turkderm Deri Hastaliklari ve Frengi Arsivi, cilt.38, sa.3, ss.191-194, 2004 (Scopus) identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 38 Sayı: 3
  • Basım Tarihi: 2004
  • Dergi Adı: Turkderm Deri Hastaliklari ve Frengi Arsivi
  • Derginin Tarandığı İndeksler: Scopus, TR DİZİN (ULAKBİM)
  • Sayfa Sayıları: ss.191-194
  • Anahtar Kelimeler: Acitretin, Isotretinoin, Osteoporosis, Retinoid
  • Ondokuz Mayıs Üniversitesi Adresli: Evet

Özet

Background and design: Isotretinoin and acitretin, known as retinoids, are synthetic derivaties of vitamin A. They have been known to cause a variety of skeletal side effects. The aim of the study was to determine whether the patients receiving synthetic retinoids are under the risk of osteoporosis. Material and Method: Nineteen patients who received 0.5 mg/kg/day dose of acitretin (n=16) and isotretinoin (n=3) were included in this study. Bone mineral density (g/cm2) of left hip (neck, trochanter) and lumbar spine (L2-L4) were measured by Dual Energy X-Ray Absorptiometry before and at the sixth month of the therapy. Results: We didn't find statistically significant difference in bone mineral density (p>0.05). Conclusion: Short term (six months) isotretinoin and acitretin with a low dose of 0.5 mg/kg/day were not due to osteoporosis at the lumbar spine and the hip.