p53 and bcl-2 expression in testicular germ cell tumors

Süllü Y., Kandemir B., Yıldız L., Karagöz F., Baris S., Aydin O.

TURKISH JOURNAL OF PATHOLOGY, cilt.22, sa.3, ss.181-186, 2006 (ESCI) identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 22 Sayı: 3
  • Basım Tarihi: 2006
  • Dergi Adı: TURKISH JOURNAL OF PATHOLOGY
  • Derginin Tarandığı İndeksler: Emerging Sources Citation Index (ESCI)
  • Sayfa Sayıları: ss.181-186
  • Anahtar Kelimeler: Testis, germ cell tumour, p53, bcl-2
  • Ondokuz Mayıs Üniversitesi Adresli: Evet

Özet

To investigate the association between p53 and bcl-2 expressions and morphological and biological features of testicular germ cell tumours, tissue slides from 49 orchiectomy specimens diagnosed as testicular germ cell tumors between 1986-2002 in the Department of Pathology, Ondokuz Mayis University Faculty of Medicine were retrospectively analysed and classified. The p53 and bcl-2 expression were demonstrated immunohistochemically and the intensity of staining was graded semi-quantitatively from (+) to (++++). The p53 expression was seen in 24 of 28 (86%) seminoma cases and 12 of 16 (75%) nonseminomatous germ cell tumours. Bcl-2 expression was seen in 2 of 28 (7%) seminoma and 7 of the 16 (44%) nonseminomatous germ cell tumour cases.